Topical treatment of skin diseases is favourable due to the lower risk of systemic side effects. But however the presence of epidermal lipids on stratum corneum prevents the penetration of actives into the viable skin. Solid lipid nanoparticles (SLN) may be considered as an option for topical treatment of skin diseases. Due to its small particle size, SLN results into the formation of occlusive film on the skin surface. These results into targeted drug delivery, controlled release of actives and occlusion associated with improved skin penetration and skin hydration which makes SLN favourable for topical treatment of skin diseases. Here in this review we mention the potential of SLN in treatment of various skin diseases.
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